The year was 2008. The second wave of therapeutic biological products was just around the corner. By now it was known that many of these products were susceptible to oxidative damage by residual hydrogen peroxide left over after aeration of the aseptic processing equipment and barrier system. How sensitive these products were to low concentrations of residual hydrogen peroxide was difficult to assess because there were no obvious measurement systems capable of quickly, accurately and precisely measuring vapor phase hydrogen peroxide below a few hundred parts per billion (ppb).
The most effective and valuable new therapeutic products today are biologics, including peptides, proteins, and antibody-drug conjugates (ADCs), as well as cells, cell-derived products, and gene therapies. Many of these products are susceptible to oxidative damage by trace levels of hydrogen peroxide.
Anyone who has watched a hummingbird frantically sip from a flower or feeder can appreciate how beautiful, hyperactive, and hungry these tiny birds are. It often seems that they are constantly on the move, fiendishly searching for and defending the flowers that contain the sugary nectar they depend on.
In this second part of the 2-part blog series on Real-Time Indoor Air Measurements of Ammonia, we present a short summary of House Observations of Microbial and Environmental Chemistry (HOMEChem), part of the Indoor Chem Project (https://indoorchem.org/). Enjoy!
In part 1 of this blog series, we explore how iCHEAR used a Picarro G2103 analyzer to provide real-time measurements of ammonia emissions to separate the contribution of exhaled and dermally emitted pollutants. What proportion of human emissions do you think can be measured and what proportion remain “missing”? Read on.
There are not many countries in the world left where you can truly say that they are blessed with intact native tropical forests. Of course we all know about the Amazon, but if we have a closer look it becomes clear that even the ‘Green hell’ as the Amazon basin has been labelled, is heavily affected by humans.
At Picarro, we enjoy hearing how research groups are using our systems in their projects. Christopher Hackney and Daniel Parsons from the University of Hull (UK) are working on a series of UK Research Council and Newton Fund funded projects(e.g. http://www.stelar-s2s.org) with partners from the Universities of Southampton, Exeter (UK), Illinois (USA) and Can Tho (Vietnam) and the Southern Institute of Water Resources Research (Vietnam)on the Mekong Delta in SE Asia.
As biologics have supplanted small molecules as the dominant focus for many leading pharmaceutical companies, robust manufacturing processes for isolators and RABS continues to be an evolving process. In this environment, as the need for significantly better VHP monitoring has grown quickly, Picarro H2O2 analyzers have increased in popularity.
Monitoring isotopic composition (δ18O, δD) of water vapor, precipitation and snow surface in the Antarctic region.
Anna Kozachek of the Arctic and Antarctic Research Institute (AARI), Saint Petersburg has taken time to write a description of her team’s use of the Picarro L2130-i and L2120-i during the Antarctic Circumnavigation Expedition (ACE) project. The main goal of the expedition was to circumnavigate Antarctica, performing oceanographic and meteorological observations along the route as well as terrestrial observations on the sub-Antarctic and Antarctic islands. Learn more about their setup and overall findings.
Investigating Experimental Priming Effects in Anaerobic Decomposition of Peats from Discontinuous Permafrost in Canada
Accelerated rates of warming and wildfires in northern regions of Canada will result in an extensive thaw of permafrost peatlands and peat plateaus. This could result in the potential release of greenhouse gases to the atmosphere. The Department of Renewable Resources at the University of Alberta, Canada have taken time to explain how they are using the Picarro G2201-I analyzer and Small Sample Introduction Module (SSIM) to further investigate if substrate addition “primes” peat decomposition.
The Picarro Small Sample Introduction Module (SSIM) is designed for processing small volumes of gas samples through a Picarro analyzer. Through a minor modification, we can now expand the functionality of the SSIM so that more accurate concentration measurements can be performed on both isotopic and concentration analyzers.
If you are attending the 2018 EGU General Assembly from April 9 to 13 in Vienna, Austria, we hope you’ll attend Picarro-authored oral and poster presentations. Following is a list of the presentations with day, date and times, location, title, and authors: Oral Presentation EGU2018-11101 Fri, 13 Apr, 16:30, Room 0.88 Quantification of atmospheric for formaldehyde by near-infrared cavity ring-down spectroscopy Chris Rella et al.
This is the third, and final, post in a three-part series that examines how Picarro analyzers, systems, and accessories ensure precise, accurate measurements of challenging seawater and high-saline water samples. The first post, Water Stable Isotope Measurements of Seawater, presents results from an inter-laboratory study designed to evaluate the quality of cavity ring-down spectroscopy (CRDS) derived measurements compared with the consistency and values of isotope ratio mass spectrometry (IRMS) measurements.
If you are attending the 2018 EGU General Assembly from April 9 to 13 in Vienna, Austria, we hope you’ll stop by Picarro booth 28 and spend some time with Picarro team members. We welcome an opportunity to meet you and learn more about your ongoing research programs. And we’ll have Picarro isotope and gas concentration analyzers on display that may be of interest to you, including...